Oral Candidiasis

Driven by certain circumstances such as antibiotic misuse, immunosuppression or diabetes mellitus, oral candidiasis is often responsible for the appearance of a white plaque on the mucous membranes of the oral cavity and/or throat, sometimes associated with symptoms such as: burning sensation in the mouth, pain when chewing and/or swallowing, abnormal taste in the mouth and lack of taste perception.

For the diagnosisof oral candidiasis, a clinical examination and anamnesis are usually sufficient; however, it is sometimes necessary to biopsy the lesion.

Treatment usually requires the use of antifungal drug therapy.

What is oral thrush?

Candidiasis is an infection caused by the fungus Candida albicans, characterized by mucocutaneous lesions, fungemia and sometimes focal infections in different places, mainly in the vagina and mouth. The latter is called oral candidiasis, and can affect the individual at any age, although it is more frequent in children.

It is easily recognized by the appearance of a white, stained plaque on the mucous membranes of the oral cavity, especially on the tongue, reminiscent of the thrush flower.

The fungus Candida albicans lives physiologically in human mucous membranes and plays a decisive role in the digestion of sugars. When present in minimal and physiological quantities, it is considered an element of the bacterial flora, that group of good bacteria that protect the most delicate mucous membranes and contribute to the perfect assimilation and fermentation of certain nutrients.

However, in some cases, the behavior of Candida albicans can change and become pathogenic, attacking the mucous membranes it usually protects. This can occur for several reasons, firstly, a temporary lowering of the immune defenses. When a Candida albicans infection occurs, the proliferating fungi are no longer considered healthy and, in that case, if they come into contact with another person, they are infectious. Transmission in the case of oral Candida can occur through the exchange of fluids, such as kissing, or by sharing kitchen utensils.

Causes

Oral candidiasis arises when, for whatever reason, the defense mechanisms intended to control the proliferation ofCandida albicans in the mouth and throat fail .

Among the factors that affect the efficacy of defense mechanisms are:

• Incorrect or excessive use of antibiotics. Excessive use of antibiotics causes the depletion of the component of the bacterial flora that is responsible for controlling the proliferation of microorganisms such as Candida albicans.
• Suffering from immunosuppression. In medicine, the word "immunosuppression" indicates a weakening of the immune system and the resulting susceptibility to infections. Immunosuppression is a typical problem for those suffering from diseases such as AIDS or cancer, those taking immunosuppressive drugs, chemotherapy or inhaled corticosteroids, those undergoing radiation therapy and the elderly, among others.
• Suffering from diabetes mellitus. In diabetic individuals, the high amount of glucose in the blood (high glycemia) and, more generally, in the whole organism, favors the multiplication of the fungus Candida albicansThis is an almost inexhaustible source of nourishment for the fungus.
• Presence of dental prosthesis. Especially if they are not cleaned properly and if they are also used during the night without giving the mucous membranes a rest. Dentures tend to create an ideal environment inside the mouth for the growth of Candida albicans.
• Xerostomia (or dry mouth). Lack of saliva deprives the mouth of an antimicrobial substance that protects against certain infections, including oral candida.
• Poor diet. Dietary deficiencies of iron, vitamin B12 and/or folic acid, and a diet rich in sweet foods favor the growth of Candida albicans in the mouth.
• Tobacco. It is not yet clear how smoking promotes oral candidiasis; however, it appears that tobacco contains a substance that facilitates the proliferation of Candida albicans in the mouth.

It should be noted that, although it occurs very rarely, even people in good health who do not fall into any of the above risk categories can develop oral candidiasis.

Symptoms

Fortunately, recognizing oral candidiasis is very simple since it presents clear and evident symptoms from the, usually no specific test is necessary to diagnose candida, but a check-up with the family doctor, the dentist or the pharmacist is enough. Only in cases where there are continuous recurrences of oral candidiasis is it advisable to follow a thorough diagnostic procedure to identify the hidden causes, the dentist being the most appropriate professional to perform this task.

The initial symptoms of oral Candida consist mainly of altered taste, redness and the presence of thick, white, bulky patches inside the mouth and on the tongue. In children and infants, the phenomenon is much more noticeable, as their oral cavity becomes completely white, as if covered by pads that start from the tongue and merge into a more compact mass; whereas, in adults, the symptom of oral candidiasis is limited, in most cases, to small whitish or yellowish plaques in the form of a mouth ulcer, which do not heal quickly.

Occasionally, other symptoms may appear, such as frequent pain in the mucous membranes, which may range from mild discomfort with an itching sensation to intense burning with bloody discharge. Often there is also a feeling of swelling of the lips, mouth and throat with swallowing problems; while fever, sweating and intestinal or gastrointestinal disturbances are rarely observed.

Treatment

The treatment of oral candidiasis is based, firstly, on pharmacological therapy with antifungal drugs, the aim of which is to eliminate the fungal colony responsible for the infection; secondly, it involves special attention to oral hygiene.

The antifungal drugs most commonly used in the presence of oral Candida are fluconazole, clotrimazole, miconazole and nystatin: the first belongs to the triazole category; the second and third are two imidazole derivatives; finally, the fourth is an antibiotic with antifungal properties.

If fluconazole, clotrimazole, miconazole and nystatin are not effective, the pharmacological treatment becomes itraconazole, another triazole, or amphotericin B, a polyene macrolide.

The route of administration of the above-mentioned drugs varies according to the severity of the infection. In the case of mild or moderate infections, it is orally, through capsules or tablets; in the case of severe infections, it is intravenously.

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Prevention of oral candidiasis

The main measures to prevent oral candidiasis are:

• During antibiotic therapy, respect the doses prescribed by the physician responsible for the treatment.
• In the presence of conditions that favor the appearance of oral candidiasis (e.g. diabetes, AIDS, immunosuppression, etc.), take the utmost care with oral hygiene, performing adequate brushing three times a day and completing oral hygiene with the use of mouthwashes and accessories for cleaning the interdental space and the tongue.
• Limit consumption of foods rich in sugar.
• Carefully treat Candida albicans infections in other parts of the body, e.g., breast Candida, vaginal Candida, etc.
• In the case of users of dental prostheses, they should be removed at night and washed periodically.
• Perform periodic dental check-ups.

For people with diabetes mellitus, blood sugar levels must be kept under control, through diet, physical activity and possibly medication.